By Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy
Released due to the fact that 1953, Advances in Virus examine covers a various variety of in-depth experiences supplying a priceless review of the present box of virology. The influence issue for 2006 is 3.48 putting it seventh within the hugely aggressive class of virology. * Contributions from prime specialists * Informs and updates on all of the newest advancements within the box
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Additional info for Advances in Virus Research, Vol. 72
The last case involved a local 15 year-old Senegalese boy presenting near Kedougou with a malaria-like disease. He developed mild arthralgia that lasted nearly a month without any other symptoms. , 2008b). From 1964– 1968, 14 of the 32 strains of DENV isolated from febrile patients were classified as DENV-2, of which 10 strains were isolated in 1966. , 2008b). Although there are no written records on the above patients’ locations of residence or places of exposure, all resided within the Ibadan city limits.
1999) and proved useful for virulence testing of DENV vaccine 38 A Nikos Vasilakis and Scott C. p. ~4–6 wks IL-4 + GM-CSF selection of CD14+ monocytes 6–7 days 200 Counts Development of peritoneal tumors 160 Isotype 120 DC-SIGN 80 CD83 40 0 0 10 1 103 102 10 Mouse IgG2a FITC Confirm immature status of mo-DCs by FACS 104 Infect immature mo-DCs with DENV (MOI= 2) Inject 1ϫ104 virus directly into tumor 2 days 7 days Collect serum, isolate and characterize virus in tumor, liver, brain Collect supernatant and quantify virus output FIGURE 8 Surrogate human models of DENV used to estimate the infection phenotypes of sylvatic versus endemic DENV-2 strains.
IV. EVOLUTION A. DENV evolutionary relationships—origins and emergence Gubler’s (Gubler, 1997) hypothesis that endemic DENV evolved from sylvatic progenitors has been the subject of intense discussion and speculation. As mentioned above, sylvatic DENV cycles occur in the forests of West Africa and Southeast Asia involving only the DENV-2 serotype in the former region, whereas in the latter all four serotypes may be represented. Virus maintenance in both regions involves sylvatic Aedes spp. mosquito vectors, and presumably non-human primates serving as reservoir hosts.
Advances in Virus Research, Vol. 72 by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy