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Extra resources for Annual Review of Immunology Volume 20 2002

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Positive selection of lymphocytes. Cell 76:219–28 Nossal GJ. 1994. Negative selection of lymphocytes. Cell 76:229–39 Viret C, Wong FS, Janeway CA Jr. 1999. Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity 10:559–68 Brocker T. 1997. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med. 186:1223–32 Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B.

These authors postulate that some of the unique functions of dendritic cells could be attributed to PD-L2 expression. Further studies will be necessary to sort out these discrepancies in expression patterns. Interestingly, mitogen or TCR activation of murine and human T cells results in cell surface expression of PD-L1 in addition to PD-1 (73) (L. Carter, B. Carreno, unpublished observations). Similarly, BCR-activated B cells express PD-L1 and PD-L2 in addition to PD-1 (63, 71, 72). Thus, B and T cell function can be modulated by engagement of cell-surface PD-1.

Acad. Sci. USA. 98:9243–48 Levine MH, Haberman AM, Sant’Angelo DB, Hannum LG, Cancro MP, Janeway CA Jr, Shlomchik MJ. 2000. A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc. Natl. Acad. Sci. USA 97:2743–48 Jerne NK. 1974. Towards a network the- 27. 28. 29. 30. ory of the immune system. Ann. Immunol. (Paris) 125C:373–89 Sakato N, Janeway CA Jr, Eisen HN. 1977. Immune responses of BALB/c mice to the idiotype of T15 and of other myeloma proteins of BALB/c origin: implications for an immune network and antibody multispecificity.

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Annual Review of Immunology Volume 20 2002 by Annual Reviews

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