By Margaret Ackerman, Falk Nimmerjahn
Antibody Fc is the 1st unmarried textual content to synthesize the literature at the mechanisms underlying the dramatic variability of antibodies to steer the immune reaction. The ebook demonstrates the significance of the Fc area, together with protecting mechanisms, effector mobilephone kinds, genetic facts, and variability in Fc area functionality. This quantity is a serious single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers in addition to graduate scholars in immunology and vaccinology.
Antibodies signify the correlate of defense for varied vaccines and are the main quickly turning out to be type of gear, with functions starting from melanoma and infectious affliction to autoimmunity. Researchers have lengthy understood the variable area of antibodies, that are accountable for antigen attractiveness, and will offer defense through blocking off the functionality in their objective antigen. besides the fact that, contemporary advancements in our knowing of the security mediated by way of antibodies have highlighted the serious nature of the antibody consistent, or Fc area, within the organic task of antibodies. The Fc area permits antibodies to hyperlink the adaptive and innate immune platforms, supplying specificity to quite a lot of innate effector cells. moreover, they supply a suggestions loop to control the nature of the immune reaction through interactions with B cells and antigen-presenting cells.
- Clarifies the various mechanisms of IgG job on the point of the various version structures used, together with human genetic, mouse, and in vitro
- Covers the position of antibodies in melanoma, infectious illness, and autoimmunity and within the atmosphere of monoclonal antibody treatment in addition to obviously raised antibodies
- Color illustrations improve motives of the immune system
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Additional resources for Antibody Fc. Linking Adaptive and Innate Immunity
Marois L, Vaillancourt M, Marois S, Proulx S, Pare G, Rollet-Labelle E, et al. The ubiquitin ligase c-Cbl down-regulates FcγRIIa activation in human neutrophils. J Immunol 2009;182(4):2374–84. Vidarsson G, Stemerding AM, Stapleton NM, Spliethoff SE, Janssen H, Rebers FE, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood 2006;108(10):3573–9. Regnault A, Lankar D, Lacabanne V, Rodriguez A, Thery C, Rescigno M, et al. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.
Immune complex-induced enhancement of bacterial antigen presentation requires Fcγ receptor III expression on dendritic cells. Proc Nat Acad Sci USA 2007;104(33):13402–7. Riquelme SA, Bueno SM, Kalergis AM. IgG keeps virulent Salmonella from evading dendritic cell uptake. Immunology 2012;136(3):291–305. Joller N, Weber SS, Müller AJ, Spörri R, Selchow P, Sander P, et al. Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. Proc Nat Acad Sci USA 2010;107(47):20441–6.
Either bacteria escape from the phagosome to escape the hostile lysosomal environment (Francisella, Listeria) or they modulate phagosome maturation to avoid acidification (Legionella, Mycobacteria). A last class of bacteria has evolved to thrive within the low pH in phagolysosomes (Coxiella). Because these intracellular bacteria are well hidden and thus not accessible to humoral immunity, protection against intracellular pathogens was long thought to be mediated by innate and adaptive cellular immunity.
Antibody Fc. Linking Adaptive and Innate Immunity by Margaret Ackerman, Falk Nimmerjahn