By Charles H. Nightingale, Takeo Murakawa, Paul G. Ambrose (Editors)
This up to the moment reference explores the pharmacodynamics of antimicrobials in addition to the absorption, distribution, metabolism, and removing of the main periods of antimicrobials-covering new brokers akin to ketolide antibiotics and highlighting the pharmacodynamic courting among drug focus and antimicrobial task, in addition to the connection of pharmacodynamics to bacterial resistance. comprises particular examples and useful purposes for the layout of powerful dosing regimens! Written by means of well-known specialists within the box, Antimicrobial Pharmacodynamics in idea and scientific perform describes ·the pharmacodynamic homes of all significant sessions of antibiotics ·parameters for microbiological job of antimicrobial brokers akin to minimum inhibitory focus (MIC) and minimum bactericidal focus (MBC) ·serum/tissue protein binding and penetration premiums ·differences among in vivo and in vitro postantibiotic results (PAE) ·and extra! With approximately a thousand references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in concept and scientific perform is a cutting-edge reference for infectious disorder experts, pulmonologists, pharmacists, pharmacologists, microbiologists, organic chemists, epidemiologists, internists, and scholars in those disciplines.
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Additional info for Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 1st Edition (Infectious Disease and Therapy)
Tauber MG, Zak O, Scheld WM, Hengstler B, Sande MA. The postantibiotic effect in the treatment of experimental meningitis caused by Streptococcus pneumoniae in rabbits. J Infect Dis 1984; 149:575–583. 81. Ter Braak EW, De Vries PJ, Bouter KP, Van der Vegt SG, Dorrestein GC, Northier JW, Van Dijk A, Verkooyen RP, Verbrugh HA. Once-daily dosing regimen for aminoglycoside plus β-lactam combination therapy of serious bacterial infections: Comparative trial with netilmicin plus ceftriaxone. Am J Med 1990; 89:58–66.
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Equation (9) can be used to correct for bacterial loss when the duration of study does not exceed 8 h. However, results of Keil and Wiedemann’s study revealed that Eq. (15) should be used when the duration of the experiment exceeds 12 h . In addition, using a value of 1 for f results in kill curves representing the worst-case scenario, so that the antibacterial effect is not overestimated. Unfortunately, this study additionally showed that individual corrections must be performed for different bacterial species and model apparatuses.
Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 1st Edition (Infectious Disease and Therapy) by Charles H. Nightingale, Takeo Murakawa, Paul G. Ambrose (Editors)